In a recent study, Nakano and coworkers explored the role of the amelogenin gene, which produces the amelogenin protein crucial for enamel formation. Our findings revealed that miR-exon4, a miRNA originating from exon4 of the amelogenin gene, targets the transcription factor nuclear factor I/A (NFI/A) and another gene, Prkch. Both of these genes have significant influence on the Runt-related transcription factor 2 (Runx2), essential for bone development. These insights hold promise for potential clinical applications to use this amelogenin derived miRNA to regulate bone growth. Link to article